Category
Central Nervous System
| Disorder | Test system | Evaluation method, etc. |
|---|---|---|
| Dementia | Tauopathy mouse model | Y maze test |
| Dementia | Tauopathy mouse model | Passive avoidance test |
| Dementia | Amyloid-β induced mouse model | Y maze test |
| Dementia | Amyloid-β induced mouse model | Passive avoidance test |
| Dementia | α-Synuclein induced mouse model | Y maze test |
| Dementia | Ibotenic acid injection model | Morris water maze test |
| Dementia | Scopolamine model | Passive avoidance test |
| Dementia | Scopolamine model | Morris water maze test |
| Dementia | PS2xAPP transgenic mice (peripheral symptoms) | Elevated plus maze test |
| Dementia | PS2xAPP transgenic mice (peripheral symptoms) | Open field test |
| Dementia | PS2xAPP transgenic mice (peripheral symptoms) | Social interaction test |
| Dementia | PS2xAPP transgenic mice (core symptoms) | Y maze test |
| Dementia | PS2xAPP transgenic mice (core symptoms) | Novel object recognition test |
| Dementia | PS2xAPP transgenic mice (core symptoms) | Morris water maze test |
| Dementia | PS2xAPP transgenic mice (core symptoms) | Passive avoidance test |
| Dementia | PS2xAPP transgenic mice (core symptoms) | Fear conditioning test |
| Dementia | PS2xAPP transgenic mice (core symptoms) | Microdialysis method |
| Dementia | PS2xAPP transgenic mice (core symptoms) | Histopathological examination (β amyloid staining) |
| Dementia | Thiamine deficiency model (core symptoms) | Passive avoidance test |
| Dementia | Senescence-Accelerated Mouse (SAM) | Passive avoidance test |
| Parkinson's disease | 6-OHDA-induced model | L-DOPA-induced rotational behavior |
| Parkinson's disease | 6-OHDA-induced model | Microdialysis method |
| Parkinson's disease | Dyskinesia model | Abnormal Involuntary Movement (AIM) score |
| Parkinson's disease | Dyskinesia model | Brain monoamine content |
| Parkinson's disease | Rotenone-induced model | Locomotor activity |
| Parkinson's disease | Rotenone-induced model | Rotarod test |
| Parkinson's disease | Rotenone-induced model | Brain monoamine content |
| Parkinson's disease | Rotenone-induced model | Histopathological examination (TH staining) |
| Parkinson's disease | Rotenone-induced model (cognitive dysfunction) | Morris water maze test |
| Parkinson's disease | Rotenone-induced model (cognitive dysfunction) | Passive avoidance test |
| Anxiety | Social defeat stress model | Elevated plus maze test |
| Anxiety | Social defeat stress model | Number of sexual activities |
| Anxiety | Social defeat stress model | Brain monoamine content |
| Anxiety | Thiamine deficiency model (peripheral symptoms) | Elevated plus maze test |
| Depression | Olfactory bulbectomy model | Emotional hyperreactivity |
| Depression | Olfactory bulbectomy model | Elevated plus maze test |
| Depression | Olfactory bulbectomy model | Open field test |
| Depression | Olfactory bulbectomy model | Brain monoamine content |
| Depression | Olfactory bulbectomy model | Microdialysis method |
| Depression | Olfactory bulbectomy model | Histopathological examination (TUNEL staining, GFAP staining) |
| Depression | Thiamine deficiency model (peripheral symptoms) | Forced swimming test |
| Schizophrenia | Phencyclidine (PCP) sub-chronic administration model | Forced swimming test |
| Schizophrenia | Phencyclidine (PCP) sub-chronic administration model | PCP-induced locomotor activity |
| Schizophrenia | Neonatal phencyclidine (PCP) administration model | Social interaction test |
| Schizophrenia | Neonatal phencyclidine (PCP) administration model | Morris water maze test |
| Schizophrenia | Neonatal phencyclidine (PCP) administration model | PCP-induced locomotor activity |
| Schizophrenia | Neonatal ventral hippocampal lesion model | Daily activity amount |
| Schizophrenia | Neonatal ventral hippocampal lesion model | Prepulse inhibition (PPI) test |
| Schizophrenia | Neonatal ventral hippocampal lesion model | Morris water maze test |
| Schizophrenia | Neonatal ventral hippocampal lesion model | Brain monoamine content |
| Schizophrenia | Acute MK-801 administration model | MK-801-induced locomotor activity |
| Schizophrenia | Acute MK-801 administration model | Prepulse inhibition (PPI) test |
| Autism spectrum disorder | Genetically modified model (Mecp2 KO) | Social interaction test |
| Autism spectrum disorder | Genetically modified model (Mecp2 KO) | Morris water maze test |
| Autism spectrum disorder | Genetically modified model (Mecp2 KO) | Acetylcholine content |
| Autism spectrum disorder | Genetically modified model (Mecp2 KO) | Brain monoamine content |
| Autism spectrum disorder | Genetically modified model (Fmrl KO) | Social interaction test |
| Autism spectrum disorder | Genetically modified model (Fmrl KO) | Reversal learning in Morris water maze |
| Autism spectrum disorder | Genetically modified model (Fmrl KO) | Brain monoamine content |
| Autism spectrum disorder | Somatosensory processing disorder model | Social interaction test |
| Autism spectrum disorder | Somatosensory processing disorder model | Gap crossing test |
| Autism spectrum disorder | Somatosensory processing disorder model | Acetylcholine content |
| Autism spectrum disorder | Somatosensory processing disorder model | Brain monoamine content |
| Mental fatigue | Water immersion breeding model | Forced swimming time |
| Sleeping disorder | Normal sleep brain wave measurement | EEG measurement |
| Sleeping disorder | Sleep inhibition model (evaluation of sleep-inducing effect) | EEG measurement |
| Sleeping disorder | Sleep deprivation model (evaluation of awakening function) | EEG measurement |
| Hearing loss | Age-related hearing loss model | Auditory brainstem response (ABR) |
| Hearing loss | Noise-induced hearing loss model | Auditory brainstem response (ABR) |
| Hearing loss | Noise-induced hearing loss model | |
| Hearing loss | Tympanic membrane perforation model | Auditory brainstem response (ABR) |
| Brain stroke | Middle cerebral artery occlusion/reperfusion model (MCAO/R model) | Neurological symptoms |
| Brain stroke | Middle cerebral artery occlusion/reperfusion model (MCAO/R model) | Histopathological examination |
| Corneal damage | Corneal epithelial disorder model | Dye staining area |
| Pain | Sciatic nerve constriction (CCI) model (Bennett model) | Thermal stimulation (withdrawal latency) |
| Pain | Sciatic nerve constriction (CCI) model (Bennett model) | Tactile stimulation (withdrawal threshold) |
| Pain | Spinal nerve ligation (SNL) model (chung model) | Thermal stimulation (withdrawal latency) |
| Pain | Spinal nerve ligation (SNL) model (chung model) | Tactile stimulation (withdrawal threshold) |
| Pain | Chemotherapy-induced peripheral neuropathy: CIPN/Oxaliplatin-induced peripheral neuropathy model | Cold stimulation (withdrawal latency) |
| Pain | Chemotherapy-induced peripheral neuropathy: CIPN/Oxaliplatin-induced peripheral neuropathy model | Tactile stimulation (withdrawal threshold) |
| Pain | Chemotherapy-induced peripheral neuropathy: CIPN/Paclitaxel-induced peripheral neuropathy model | Tactile stimulation (withdrawal threshold) |
| Pain | Chemotherapy-induced peripheral neuropathy: CIPN/Cisplatin-induced peripheral neuropathy model | Tactile stimulation (withdrawal threshold) |
| Pain | Fibromyalgia (Sluka) model | Tactile stimulation (withdrawal threshold) |
| Pain | Diabetic peripheral neuropathy model | Tactile stimulation (withdrawal threshold) |
| Pain | Diabetic peripheral neuropathy model | Motor nerve conduction velocity |
| Pain | Adjuvant-induced hyperalgesia model | Thermal stimulation (withdrawal latency) |
| Pain | Adjuvant-induced hyperalgesia model | Tactile stimulation (withdrawal threshold) |
| Pain | Adjuvant-induced hyperalgesia model | Vocalization response |
| Pain | Adjuvant-induced hyperalgesia model | Pressure stimulation |
| Pain | Carrageenin-induced hyperalgesia model | Tactile stimulation (withdrawal threshold) |
| Pain | Capsaicin patch hyperalgesia model | Thermal stimulation (withdrawal latency) |
| Pain | Capsaicin patch hyperalgesia model | Tactile stimulation (withdrawal threshold) |
| Pain | Acetic acid-induced abdominal pain model | Writhing number |
| Pain | Acetylcholine-induced abdominal pain model | Writhing number |
| Pain | Intermittent cold stress (ICS) model | Tactile stimulation (withdrawal threshold) |
| Pain | Postherpetic neuralgia model | Tactile stimulation (withdrawal threshold) |
Inflammation / Immune Diseases
| Disorder | Test system | Evaluation method, etc. |
|---|---|---|
| Rheumatoid arthritis | Adjuvant arthritis model | Edema rate |
| Rheumatoid arthritis | Adjuvant arthritis model | Arthritis score |
| Rheumatoid arthritis | Adjuvant arthritis model | Histopathological examination |
| Rheumatoid arthritis | Collagen-induced arthritis model | Edema rate |
| Rheumatoid arthritis | Collagen-induced arthritis model | Arthritis score |
| Rheumatoid arthritis | Collagen-induced arthritis model | Histopathological examination |
| Osteoarthritis | MIA-induced osteoarthritis model | Histopathological examination |
| Edema | Croton oil-induced ear edema model | Ear weight |
| Edema | Croton oil-induced ear edema model | Ear thickness |
| Edema | Oxazolone-induced ear edema model | Ear weight |
| Edema | Oxazolone-induced ear edema model | Ear thickness |
| Edema | Carrageenin-induced limb edema model | Edema rate |
| Itchiness | Compound 40/80-induced itch model | Scratching behavior |
| Itchiness | Histamine-induced itch model | Scratching behavior |
| Itchiness | Substance P-induced itch model | Scratching behavior |
| Atopic dermatitis | PiCl-induced atopic dermatitis model | Dermatitis score |
| Atopic dermatitis | PiCl-induced atopic dermatitis model | Histopathological examination |
| Atopic dermatitis | PiCl-induced atopic dermatitis model | Blood chemical analysis (IgE) |
| Atopic dermatitis | PiCl-induced atopic dermatitis model | Scratching behavior |
| Atopic dermatitis | Mite antigen-induced atopic dermatitis model | Dermatitis score |
| Atopic dermatitis | Mite antigen-induced atopic dermatitis model | Histopathological examination |
| Atopic dermatitis | Mite antigen-induced atopic dermatitis model | Blood chemical analysis (IgE) |
| Atopic dermatitis | Mite antigen-induced atopic dermatitis model | Scratching behavior |
| Allergic dermatitis | PiCl-induced type IV allergic dermatitis model | Ear thickness |
| Allergic dermatitis | DNFB-induced allergic dermatitis model | Dermatitis score |
| Allergic dermatitis | DNFB-induced allergic dermatitis model | Histopathological examination |
| Allergic dermatitis | DNFB-induced allergic dermatitis model | Erythema meter |
| Allergic conjunctivitis | Croton oil-induced allergic conjunctivitis model | Eyelid weight |
| Psoriasis | Imiquimod-induced psoriasis model | Dermatitis score |
| Psoriasis | Imiquimod-induced psoriasis model | Histopathological examination |
| Psoriasis | Imiquimod-induced psoriasis model | Blood chemical analysis |
| Wound | Wound healing model | Defect area |
| Wound | Wound healing model | Healing period |
| Wound | Wound healing model | Histopathological examination |
| Wound | Skin incision model | Wound tension strength |
| Pulmonary fibrosis | Bleomycin-induced pulmonary fibrosis model | Histopathological examination |
| Pulmonary fibrosis | Bleomycin-induced pulmonary fibrosis model | Hydroxyproline |
| High fever | Yeast-induced fever model | Body temperature |
Kidney / Urinary System
| Disorder | Test system | Evaluation method, etc. |
|---|---|---|
| Acute kidney injury | Ischemic acute kidney injury model | Blood chemical analysis |
| Acute kidney injury | Ischemic acute kidney injury model | Histopathological examination |
| Acute kidney injury | Ischemic acute kidney injury model | Urinalysis |
| Acute kidney injury | Contrast agent-induced acute kidney injury model | Blood chemical analysis |
| Acute kidney injury | Contrast agent-induced acute kidney injury model | Urinalysis |
| Acute kidney injury | Contrast agent-induced acute kidney injury model | Histopathological examination |
| Acute kidney injury | Cisplatin-induced acute kidney injury model | Blood chemical analysis |
| Acute kidney injury | Cisplatin-induced acute kidney injury model | Histopathological examination |
| Chronic kidney disease | Adenine nephropathy model | Blood chemical analysis |
| Chronic kidney disease | Adenine nephropathy model | Histopathological examination |
| Chronic kidney disease | Adenine nephropathy model | Calcium and phosphorus in tissues |
| Chronic kidney disease | Streptozotocin-induced diabetic nephropathy model | Blood chemical analysis |
| Chronic kidney disease | Streptozotocin-induced diabetic nephropathy model | Urinalysis |
| Chronic kidney disease | Streptozotocin-induced diabetic nephropathy model | Histopathological examination |
| Chronic kidney disease | Bilateral nephrectomy dialysis model | Blood chemical analysis |
| Chronic kidney disease | Bilateral nephrectomy dialysis model | Urinalysis |
| Chronic kidney disease | Unilateral ureteral ligation (UUO) model | Hydroxyproline |
| Chronic kidney disease | Unilateral ureteral ligation (UUO) model | Histopathological examination |
| Chronic kidney disease | Thy-1 nephritis model | Blood chemical analysis |
| Chronic kidney disease | Thy-1 nephritis model | Urinalysis |
| Chronic kidney disease | Thy-1 nephritis model | Histopathological examination |
| Frequent urination | Bladder function evaluation model | Cystometry |
| Prostatic hypertrophy | Urethral function evaluation model | Urethral manometry |
Metabolic System
| Disorder | Test system | Evaluation method, etc. |
|---|---|---|
| Obesity | High-fat diet-induced obesity model | Blood chemical analysis (neutral fat, leptin, adiponectin) |
| Obesity | High-fat diet-induced obesity model | Visceral fat weight |
| Obesity | Obese model (Zucker Fatty) | Blood chemical analysis (neutral fat, leptin, adiponectin) |
| Obesity | Obese model (Zucker Fatty) | Visceral fat weight |
| Arteriosclerosis | Cholesterol loading model | Blood chemical analysis |
| Arteriosclerosis | Cholesterol loading model | Aortic lesion area |
| Arteriosclerosis | Cholesterol loading model | Histopathological examination (aorta, coronary artery) |
| Arteriosclerosis | Genetically modified arteriosclerosis model (apoEKO mouse) | Blood chemical analysis |
| Arteriosclerosis | Genetically modified arteriosclerosis model (apoEKO mouse) | Aortic lesion area |
| Arteriosclerosis | Genetically modified arteriosclerosis model (apoEKO mouse) | Histopathological examination (aorta, coronary artery) |
| Arteriosclerosis | Spontaneous arteriosclerosis model (WHHL) | Blood chemical analysis |
| Arteriosclerosis | Spontaneous arteriosclerosis model (WHHL) | Aortic lesion area |
| Arteriosclerosis | Spontaneous arteriosclerosis model (WHHL) | Histopathological examination (aorta, coronary artery) |
| Hyperlipidemia | High fat feed loading model | Blood chemical analysis (neutral fat, etc.) |
| Hyperlipidemia | High cholesterol feed loading model | Blood chemical analysis (neutral fat, etc.) |
| Liver damage | Carbon tetrachloride-induced liver injury model | Blood chemical analysis (liver enzymes) |
| Liver damage | Carbon tetrachloride-induced liver injury model | Histopathological examination (liver) |
| Liver damage | Galactosamine-induced acute liver failure model | Blood chemical analysis (liver enzymes) |
| Liver damage | Galactosamine-induced acute liver failure model | Histopathological examination (liver) |
| Liver damage | Acetaminophen-induced liver injury model | Blood chemical analysis (liver enzymes) |
| Liver damage | Acetaminophen-induced liver injury model | Histopathological examination (liver) |
| Steatohepatitis | Nonalcoholic steatohepatitis model (NASH) | Histopathological examination (liver) |
| Steatohepatitis | Nonalcoholic steatohepatitis model (NASH) | Blood chemical analysis (liver enzymes) |
| Diabetes | Streptozotocin-induced diabetes model (type 1 diabetes) | Blood chemical analysis (blood glucose, insulin, glycated hemoglobin) |
| Diabetes | Streptozotocin-induced diabetes model (type 1 diabetes) | Nerve conduction velocity |
| Diabetes | Streptozotocin-induced diabetes model (type 1 diabetes) | Glucose tolerance test |
| Diabetes | Streptozotocin-induced diabetes model (type 1 diabetes) | Histopathological examination |
| Diabetes | Streptozotocin-induced diabetes model (type 1 diabetes) | Retinal evoked potential (ERG) |
| Diabetes | Streptozotocin-induced diabetes model (type 1 diabetes) | Cystometry |
| Diabetes | Pancreatectomy diabetes model (type 1 diabetes) | Blood chemical analysis (blood glucose, insulin) |
| Diabetes | Pancreatectomy diabetes model (type 1 diabetes) | Glucose tolerance test |
| Diabetes | Pancreatectomy diabetes model (type 1 diabetes) | Histopathological examination |
| Diabetes | Type 2 diabetes model (KK-Ay) | Blood chemical analysis (blood glucose, insulin, glycated hemoglobin) |
| Diabetes | Type 2 diabetes model (KK-Ay) | Glucose tolerance test |
| Diabetes | Type 2 diabetes model (KK-Ay) | Retinal evoked potential (ERG) |
| Diabetes | Obese type 2 diabetes model (db/db) | Blood chemical analysis (blood glucose, insulin, glycated hemoglobin) |
| Diabetes | Obese type 2 diabetes model (db/db) | Glucose tolerance test |
| Diabetes | Obese type 2 diabetes model (db/db) | Retinal evoked potential (ERG) |
| Diabetes | Obese type 2 diabetes model (Zucker Diabetic Fatty) | Blood chemical analysis (blood glucose, insulin, glycated hemoglobin) |
| Diabetes | Obese type 2 diabetes model (Zucker Diabetic Fatty) | Glucose tolerance test |
| Diabetes | Obese type 2 diabetes model (Zucker Diabetic Fatty) | Retinal evoked potential (ERG) |
| Diabetes | Obese type 2 diabetes model (Zucker Diabetic Fatty) | Histopathological examination |
| Diabetes | Non-obese type 2 diabetes model (GK) | Blood chemical analysis (blood glucose, insulin, glycated hemoglobin) |
| Diabetes | Non-obese type 2 diabetes model (GK) | Glucose tolerance test |
| Diabetes | Non-obese type 2 diabetes model (GK) | Retinal evoked potential (ERG) |
| Diabetes | Non-obese type 2 diabetes model (GK) | Histopathological examination |
| Diabetes | Obese model (Zucker Fatty) | Blood chemical analysis (blood glucose, insulin, glycated hemoglobin) |
| Diabetes | Obese model (Zucker Fatty) | Glucose tolerance test |
| Diabetes | Obese model (Zucker Fatty) | Retinal evoked potential (ERG) |
| Diabetes | Obese model (Zucker Fatty) | Histopathological examination |
| Diabetes | Sodium laurate-induced peripheral artery occlusion model | Blood flow |
| Cataract | Streptozotocin-induced diabetic cataract model | Cataract incidence rate |
| Cataract | Galactose-induced cataract model | Cataract incidence rate |
| Cataract | Sodium selenite-induced cataract model | Cataract incidence rate |
| Hyperuricemia | Potassium oxonate-induced hyperuricemia model | Blood chemical analysis (uric acid) |
Digestive System
| Disorder | Test system | Evaluation method, etc. |
|---|---|---|
| Reflux esophagitis | Pylorus ligation reflux esophagitis model | Score |
| Vomiting | Anticancer drug-induced delayed emesis model | Frequency of vomiting |
| Vomiting | Anticancer drug-induced delayed emesis model | Vagal nerve action potential |
| Vomiting | Anticancer drug-induced delayed emesis model | Frequency of vomiting |
| Vomiting | Anticancer drug-induced delayed emesis model | Vomiting duration |
| Vomiting | Anticancer drug-induced delayed emesis model | Gastrointestinal motility |
| Vomiting | Drug-induced acute emesis model | Frequency of vomiting |
| Vomiting | Drug-induced acute emesis model | Vomiting duration |
| Stomach ulcer | Water immersion stress-induced gastric ulcer model | Length of gastric mucosal lesion |
| Stomach ulcer | Hydrochloric acid/ethanol-induced gastric ulcer model | Length of gastric mucosal lesion |
| Stomach ulcer | Ethanol-induced gastric ulcer model | Length of gastric mucosal lesion |
| Stomach ulcer | Indomethacin-induced gastric ulcer model | Length of gastric mucosal lesion |
| Stomach ulcer | Aspirin-induced gastric ulcer model | Length of gastric mucosal lesion |
| Ulcerative colitis | TNBS-induced colitis model | Bleeding score |
| Ulcerative colitis | TNBS-induced colitis model | Diarrhea score |
| Ulcerative colitis | TNBS-induced colitis model | Large intestine weight |
| Ulcerative colitis | TNBS-induced colitis model | Histopathological examination |
| Irritable bowel syndrome | Restraint stress-induced irritable bowel syndrome model | Frequency of defecation |
| Irritable bowel syndrome | Restraint stress-induced irritable bowel syndrome model | Number of abdominal muscle contractions |
| Diarrhea | Castor oil-induced diarrhea model | Stool weight |
| Diarrhea | Castor oil-induced diarrhea model | Fecal properties |
| Diarrhea | Picosulfate Na-induced diarrhea model | Stool weight |
| Diarrhea | Picosulfate Na-induced diarrhea model | Fecal properties |
| Diarrhea | Sennoside-induced diarrhea model | Stool weight |
| Diarrhea | Sennoside-induced diarrhea model | Fecal properties |
| Constipation | Loperamide-induced constipation model | Stool weight |
| Constipation | Loperamide-induced constipation model | Fecal properties |
| Hemorrhoids | Croton oil-induced hemorrhoids model | Rectal weight |
| Hemorrhoids | Croton oil-induced hemorrhoids model | Histopathological examination |
| Others | Restraint stress-induced gastric emptying dysfunction model | Excretion rate |
| Others | Heidenhain pouch model | Gastric juice pH |
| Others | Heidenhain pouch model | Gastric juice volume |
| Others | Continuous intragastric pH measurement model | Gastric pH |
Respiratory / Circulatory System
| Disorder | Test system | Evaluation method, etc. |
|---|---|---|
| High blood pressure | Spontaneously hypertensive rat model (SHR) | Blood pressure |
| High blood pressure | Spontaneously hypertensive rat model (SHR) | Heart rate |
| High blood pressure | Spontaneously hypertensive rat model (SHR) | Blood chemical analysis |
| High blood pressure | Stroke-prone spontaneously hypertensive rat model (SHRSP) | Blood pressure |
| High blood pressure | Stroke-prone spontaneously hypertensive rat model (SHRSP) | Heart rate |
| High blood pressure | Stroke-prone spontaneously hypertensive rat model (SHRSP) | Blood chemical analysis |
| High blood pressure | Deoxycorticosterone acetate?hypertensive model | Blood pressure |
| High blood pressure | Deoxycorticosterone acetate?hypertensive model | Heart rate |
| High blood pressure | Deoxycorticosterone acetate?hypertensive model | Blood chemical analysis |
| High blood pressure | Dahl salt sensitivity model | Blood pressure |
| High blood pressure | Dahl salt sensitivity model | Heart rate |
| High blood pressure | Dahl salt sensitivity model | Blood chemical analysis |
| High blood pressure | Two-kidney one-clip model | Blood pressure |
| High blood pressure | Two-kidney one-clip model | Heart rate |
| High blood pressure | Two-kidney one-clip model | Blood chemical analysis |
| High blood pressure | Two-kidney one-clip model | Histopathological examination |
| Hemorrhagic shock | Hemorrhagic shock model | Blood gas |
| Hemorrhagic shock | Hemorrhagic shock model | Blood pressure |
| Hemorrhagic shock | Hemorrhagic shock model | Heart rate |
| Hemorrhagic shock | Hemorrhagic shock model | Blood flow |
| Hemorrhagic shock | Hemorrhagic shock model | Blood chemical analysis |
| Asthma | Mite antigen-induced asthma model | Histopathological examination |
| Asthma | Mite antigen-induced asthma model | Number of inflammatory cells in bronchoalveolar lavage fluid |
| Pulmonary fibrosis | Bleomycin-induced pulmonary fibrosis model | Histopathological examination |
| Pulmonary fibrosis | Bleomycin-induced pulmonary fibrosis model | Hydroxyproline |
| COPD | Elastase/LPS-induced COPD model | Histopathological examination |
| Others | Spinal cord injury model | Blood pressure |
| Others | Vascular transplant study | Histopathological examination |
| Others | Vascular transplant study | Blood flow |
Bones / Muscles
| Disorder | Test system | Evaluation method, etc. |
|---|---|---|
| Sarcopenia | Hindlimb suspension model | Muscle weight |
| Sarcopenia | Hindlimb suspension model | Treadmill test |
| Sarcopenia | Natural aging model (B6J-Aged) | Rotarod test |
| Sarcopenia | Natural aging model (B6J-Aged) | Muscle weight |
| Exercise fatigue | Exercise load model | Blood chemical analysis (lactic acid level) |
| Exercise fatigue | Exercise load model | Muscle lactic acid level |
| Osteoporosis | RANKL-induced osteoporosis model | Blood chemical analysis |
| Osteoporosis | RANKL-induced osteoporosis model | Bone density |
| Osteoporosis | RANKL-induced osteoporosis model | Bone mineral |
| Osteoporosis | Ovariectomized osteoporosis model | Blood chemical analysis |
| Osteoporosis | Ovariectomized osteoporosis model | Bone density |
| Osteoporosis | Ovariectomized osteoporosis model | Bone mineral |
| Others | Muscle implantation test | Histopathological examination |
| Others | Bone implantation test | Pull-out test |
| Others | Bone implantation test | Histopathological examination |
Dentistry / Oral Surgery
| Disorder | Test system | Evaluation method, etc. |
|---|---|---|
| Periodontal disease | Periodontal disease model | X-ray |
| Periodontal disease | Periodontal disease model | Histopathological examination |
| Use simulation test | Dental pulp/dentin use simulation test | X-ray (reference data) |
| Use simulation test | Dental pulp/dentin use simulation test | Histopathological examination |
| Use simulation test | Root filling use simulation test | X-ray (reference data) |
| Use simulation test | Root filling use simulation test | Histopathological examination |
| Use simulation test | Pulp capping test | X-ray (reference data) |
| Use simulation test | Pulp capping test | Histopathological examination |
| Oral surgery | GBR method (guided bone regeneration) | Histopathological examination |
| Oral surgery | GTR method (guided tissue regeneration) | Histopathological examination |
| Oral surgery | Socket preservation | Histopathological examination |
| Oral surgery | Implant | Histopathological examination |
Skin
| Disorder | Test system | Evaluation method, etc. |
|---|---|---|
| Atopic dermatitis | PiCl-induced atopic dermatitis model | Dermatitis score |
| Atopic dermatitis | PiCl-induced atopic dermatitis model | Histopathological examination |
| Atopic dermatitis | PiCl-induced atopic dermatitis model | Blood chemical analysis (IgE) |
| Atopic dermatitis | PiCl-induced atopic dermatitis model | Scratching behavior |
| Atopic dermatitis | Mite antigen-induced atopic dermatitis model | Dermatitis score |
| Atopic dermatitis | Mite antigen-induced atopic dermatitis model | Histopathological examination |
| Atopic dermatitis | Mite antigen-induced atopic dermatitis model | Blood chemical analysis (IgE) |
| Atopic dermatitis | Mite antigen-induced atopic dermatitis model | Scratching behavior |
| Allergic dermatitis | PiCl-induced type IV allergic dermatitis model | Auricular thickness |
| Allergic dermatitis | DNFB-induced allergic dermatitis model | Dermatitis score |
| Allergic dermatitis | DNFB-induced allergic dermatitis model | Histopathological examination |
| Allergic dermatitis | DNFB-induced allergic dermatitis model | Erythema meter |
| Wound | Wound healing model | Wound area |
| Wound | Wound healing model | Healing period |
| Wound | Wound healing model | Histopathological examination |
| Wound | Skin incision model | Wound tension strength |
| Spots | UV irradiation-induced pigmentation model | L value |
| Wrinkles | UV irradiation-induced wrinkle model (hairless mouse) | Wrinkle analysis |
| Rough skin | UV irradiation-induced rough skin model | Skin moisture content |
| Rough skin | UV irradiation-induced rough skin model | Skin transpiration |
| Rough skin | Lauryl sulfate application-induced rough skin model | Skin moisture content |
| Rough skin | Lauryl sulfate application-induced rough skin model | Skin transpiration |
| Alopecia | Hair growth test | Score |
Age-Related Diseases
| Disorder | Test system | Evaluation method, etc. |
|---|---|---|
| Dementia | Senescence-Accelerated Mouse (SAM) | Passive avoidance test |
| Dementia | Natural aging model (B6J-Aged) | Morris water maze test |
| Hearing loss | Age-related hearing loss model | Auditory brainstem response (ABR) |
| Sarcopenia | Hindlimb suspension model | Muscle weight |
| Sarcopenia | Hindlimb suspension model | Treadmill test |
| Sarcopenia | Natural aging model (B6J-Aged) | Rotarod test |
| Sarcopenia | Natural aging model (B6J-Aged) | Muscle weight |
| Exercise fatigue | Exercise load model | Blood chemical analysis (lactic acid level) |
| Exercise fatigue | Exercise load model | Muscle lactic acid level |
| Cauda equina syndrome | Cauda equina compression model | Treadmill test |
| Cauda equina syndrome | Cauda equina compression model | Open field test |
| Spots | UV irradiation-induced pigmentation model | L value |
| Wrinkles | UV irradiation-induced wrinkle model (hairless mouse) | Wrinkle analysis |
| Alopecia | Hair growth test | Score |
Infection
| Disorder | Test system | Evaluation method, etc. |
|---|---|---|
| Influenza virus | Influenza virus lung infection model | Observation of lesion degree |
| Influenza virus | Influenza virus lung infection model | Virological testing |
| Influenza virus | Influenza virus lung infection model | NK activity |
| Influenza virus | Drug susceptibility testing (influenza virus) | Plaque reduction method |
| Rotavirus | Rotavirus gastrointestinal infection model | Observation of lesion degree |
| Rotavirus | Rotavirus gastrointestinal infection model | Virological testing |
| Rotavirus | Rotavirus gastrointestinal infection model | NK activity |
| Rotavirus | Drug susceptibility test (rotavirus) | Plaque reduction method |
| MRSA | MRSA systemic infection model | Observation of lesion degree |
| MRSA | MRSA systemic infection model | Bacteriological examination |
| MRSA | Drug susceptibility testing (MRSA) | Plaque reduction method |
| Staphylococcus aureus | Staphylococcus aureus systemic infection model | Observation of lesion degree |
| Staphylococcus aureus | Staphylococcus aureus systemic infection model | Bacteriological examination |
| Staphylococcus aureus | Staphylococcus aureus skin infection model | Observation of lesion degree |
| Staphylococcus aureus | Staphylococcus aureus skin infection model | Bacteriological examination |
| Staphylococcus aureus | Drug susceptibility test (Staphylococcus aureus) | Plaque reduction method |
| Helicobacter pylori (H. pylori) | Pylori gastrointestinal infection model | Observation of lesion degree |
| Helicobacter pylori (H. pylori) | Pylori gastrointestinal infection model | Bacteriological examination |
| Pseudomonas aeruginosa | Pseudomonas aeruginosa systemic infection | Observation of lesion degree |
| Pseudomonas aeruginosa | Pseudomonas aeruginosa systemic infection | Bacteriological examination |
| Pseudomonas aeruginosa | Drug susceptibility test (Pseudomonas aeruginosa) | Plaque reduction method |
| Multidrug-resistant Pseudomonas aeruginosa | Multidrug-resistant Pseudomonas aeruginosa systemic infection | Observation of lesion degree |
| Multidrug-resistant Pseudomonas aeruginosa | Multidrug-resistant Pseudomonas aeruginosa systemic infection | Bacteriological examination |
| Multidrug-resistant Pseudomonas aeruginosa | Drug susceptibility test (multidrug-resistant Pseudomonas aeruginosa) | Plaque reduction method |
| Candida | Candida systemic infection | Observation of lesion degree |
| Candida | Candida systemic infection | Bacteriological examination |
| Candida | Drug sensitivity test (Candida) | Plaque reduction method |
| Herpesvirus | Herpesvirus skin infection | Observation of lesion degree |
| Herpesvirus | Herpesvirus skin infection | Virological testing |
| Herpesvirus | Drug susceptibility test (herpesvirus) | Plaque reduction method |
| Herpesvirus | Postherpetic neuralgia model | Tactile stimulation (withdrawal threshold) |
| Coli | E. coli systemic infection model | Observation of lesion degree |
| Coli | E. coli systemic infection model | Bacteriological examination |
| Coli | Drug susceptibility test (E. coli) | Plaque reduction method |
| Salmonella | Salmonella systemic infection model | Observation of lesion degree |
| Salmonella | Salmonella systemic infection model | Bacteriological examination |
| Salmonella | Drug susceptibility test (Salmonella) | Plaque reduction method |
| Clostridium difficile infection | Clostridium difficile gastrointestinal infection model | Observation of lesion degree |
| Clostridium difficile infection | Clostridium difficile gastrointestinal infection model | Survival rate observation |
| Clostridium difficile infection | Clostridium difficile gastrointestinal infection model | Stool quality |
| Trichophyton infection | Trichophyton nail infection model | Bacteriological examination |
| Trichophyton infection | Trichophyton skin infection model | Observation of lesion degree |
| Trichophyton infection | Trichophyton skin infection model | Bacteriological examination |
| Trichophyton infection | Drug susceptibility test (Trichophyton) | Plaque reduction method |
| Feline calicivirus infection | Drug susceptibility test (feline calicivirus) | Plaque reduction method |
in vitro
| Disorder | Test system | Evaluation method, etc. |
|---|---|---|
| drug susceptibility test | Drug susceptibility testing (influenza virus) | Plaque reduction method |
| drug susceptibility test | Drug susceptibility test (rotavirus) | Plaque reduction method |
| drug susceptibility test | Drug susceptibility testing (MRSA) | Plaque reduction method |
| drug susceptibility test | Drug susceptibility test (Pseudomonas aeruginosa) | Plaque reduction method |
| drug susceptibility test | Drug susceptibility test (Staphylococcus aureus) | Plaque reduction method |
| drug susceptibility test | Drug susceptibility test (multidrug-resistant Pseudomonas aeruginosa) | Plaque reduction method |
| drug susceptibility test | Drug sensitivity test (Candida) | Plaque reduction method |
| drug susceptibility test | Drug susceptibility test (herpesvirus) | Plaque reduction method |
| drug susceptibility test | Drug susceptibility test (E. coli) | Plaque reduction method |
| drug susceptibility test | Drug susceptibility test (Salmonella) | Plaque reduction method |
| drug susceptibility test | Drug susceptibility test (Trichophyton) | Plaque reduction method |
| drug susceptibility test | Drug susceptibility test (feline calicivirus) | Plaque reduction method |
| Magnus method | Magnus method (intestinal tract) | Tension |
| Magnus method | Magnus method (aorta) | Tension |
| Magnus method | Magnus method (coronary artery) | Tension |
| Magnus method | Magnus method (trachea) | Tension |
| Magnus method | Magnus method (stomach) | Tension |
| Magnus method | Magnus method (pupil) | Tension |
| Magnus method | Magnus method (urethra) | Tension |
| Magnus method | Magnus method (bladder) | Tension |
| Magnus method | Magnus method (vas deferens) | Tension |
| Magnus method | Magnus method (uterus) | Tension |
Medical Equipment
| Disorder | Test system | Evaluation method, etc. |
|---|---|---|
| Wound | Wound healing model | Defect area |
| Wound | Wound healing model | Healing period |
| Wound | Wound healing model | Histopathological examination |
| Wound | Skin incision model | Wound tension strength |
| Chronic kidney disease | Bilateral nephrectomy dialysis model | Blood chemical analysis |
| Chronic kidney disease | Bilateral nephrectomy dialysis model | Urinalysis |
| Alopecia | Hair growth test | Score |
| Implantation | Stent implantation test | Blood flow |
| Implantation | Stent implantation test | Stenosis rate |
| Implantation | Stent implantation test | Histopathological examination |
| Others | Medical device performance testing | Histopathological examination |
| Others | Muscle implantation test | Histopathological examination |
| Others | Bone implantation test | Pull-out test |
| Others | Bone implantation test | Histopathological examination |
Regenerative Medicine Products
| Disorder | Test system | Evaluation method, etc. |
|---|---|---|
| Corneal damage | Corneal epithelial disorder model | Dye staining area |
| Hearing loss | Tympanic membrane perforation model | Auditory brainstem response (ABR) |
| Wound | Wound healing model | Defect area |
| Wound | Wound healing model | Healing period |
| Wound | Wound healing model | Histopathological examination |
| Wound | Skin incision model | Wound tension strength |
| Pulmonary fibrosis | Bleomycin-induced pulmonary fibrosis model | Histopathological examination |
| Pulmonary fibrosis | Bleomycin-induced pulmonary fibrosis model | Hydroxyproline |
| Hepatic fibrosis | Carbon tetrachloride-induced hepatic fibrosis model | Histopathological examination |
| Hepatic fibrosis | Carbon tetrachloride-induced hepatic fibrosis model | Hydroxyproline |
| COPD | Elastase/LPS-induced COPD model | Histopathological examination |
| Nerve damage | Sciatic nerve injury | Evaluation of sensation |
| Nerve damage | Sciatic nerve injury | Nerve conduction velocity |
| Nerve damage | Spinal cord injury | Motor function score |
| Nerve damage | Spinal cord injury | Histopathological examination |
| Others | Local implantation test | |
| Others | Bone implantation test | Pull-out test |
| Others | Bone implantation test | Histopathological examination |
| Others | Vascular transplant study | Blood flow |
| Others | Vascular transplant study | Histopathological examination |
| Others | Osteoarthritis model | Histopathological examination |